In this FlyBook chapter, we present a survey of the current literature on the development of
the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of …

The emergence of hematopoietic progenitors and their differentiation into various highly
specialized blood cell types constitute a finely tuned process. Unveiling the genetic …

Notch signaling is an evolutionarily conserved cell–cell communication mechanism that
plays a key role in lung homeostasis, injury and repair. The loss of regulation of Notch …

Blood cells arise from diverse pools of stem and progenitor cells. Understanding progenitor
heterogeneity is a major challenge. The Drosophila larval lymph gland is a well-studied …

The maintenance of stem or progenitor cell fate relies on intrinsic factors as well as local
cues from the cellular microenvironment and systemic signaling. In the lymph gland, an …

The production of reactive oxygen species (ROS) is a prominent response to infection
among innate immune cells such as macrophages and neutrophils. To better understand the …

Studies in different animal model systems have revealed the impact of odors on immune
cells; however, any understanding on why and how odors control cellular immunity …

Reactive oxygen species (ROS) are typically regarded as being generated by the cellular
respiratory chain or by cells under pathological damage, which play a crucial role as …

Cell-intrinsic and extrinsic signals regulate the state and fate of stem and progenitor cells.
Recent advances in metabolomics illustrate that various metabolic pathways are also …

Recent data on Duchenne muscular dystrophy (DMD) show myocyte progenitor's
involvement in the disease pathology often leading to the DMD patient's death. The …