[HTML][HTML] Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations
Maintenance therapy (MT) with oral methotrexate (MTX) and 6-mercaptopurine (6-MP) is
essential for the cure of acute lymphoblastic leukemia (ALL). MTX and 6-MP interfere with …
essential for the cure of acute lymphoblastic leukemia (ALL). MTX and 6-MP interfere with …
Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis
Background: Prevalence and impact of thiopurine S-methyltransferase (TPMT) and Nudix
hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear …
hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear …
Pharmacogenetics of childhood acute lymphoblastic leukemia
E Lopez-Lopez, A Gutierrez-Camino… - …, 2014 - Taylor & Francis
Acute lymphoblastic leukemia (ALL) is the major pediatric cancer in developed countries.
Although treatment outcome has improved owing to advances in chemotherapy, there is still …
Although treatment outcome has improved owing to advances in chemotherapy, there is still …
Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia
T Adam de Beaumais, E Jacqz-Aigrain - European journal of clinical …, 2012 - Springer
Background The backbone of drug therapy used in acute lymphoblastic leukemia (ALL) in
children includes 6-mercaptopurine (6-MP). Intracellular metabolism of this prodrug is a key …
children includes 6-mercaptopurine (6-MP). Intracellular metabolism of this prodrug is a key …
[HTML][HTML] Pharmacogenetic Analysis of Pediatric Patients with Acute Lymphoblastic Leukemia: A Possible Association between Survival Rate and ITPA Polymorphism
H Kim, HJ Kang, HJ Kim, MK Jang, NH Kim, Y Oh… - 2012 - journals.plos.org
Genetic polymorphisms are important factors in the effects and toxicity of chemotherapeutics.
To analyze the pharmacogenetic and ethnic differences in chemotherapeutics, major genes …
To analyze the pharmacogenetic and ethnic differences in chemotherapeutics, major genes …
[HTML][HTML] Effect of ITPA polymorphism on adverse drug reactions of 6-mercaptopurine in pediatric patients with acute lymphoblastic leukemia: a systematic review and …
6-Mercaptopurine (6-MP) is a cornerstone of the maintenance regimen for pediatric acute
lymphoblastic leukemia (ALL). Inosine triphosphate pyrophosphatase (ITPA) is considered a …
lymphoblastic leukemia (ALL). Inosine triphosphate pyrophosphatase (ITPA) is considered a …
[HTML][HTML] Association of NUDT15 c.415C>T and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based …
S Kodidela, P Dorababu, DN Thakkar, B Dubashi… - Genes, 2020 - mdpi.com
Genetic variants influencing the pharmacokinetics and/or pharmacodynamics of the
chemotherapeutic drugs used in Acute Lymphoblastic Leukemia (ALL) therapy often …
chemotherapeutic drugs used in Acute Lymphoblastic Leukemia (ALL) therapy often …
Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL
Aim: The rationale of this study was to explore the contribution of genetic variants of the
folate pathway to toxicity of 6-mercaptopurine (6-MP)-mediated hematological toxicity in …
folate pathway to toxicity of 6-mercaptopurine (6-MP)-mediated hematological toxicity in …
Classification and regression tree-based prediction of 6-mercaptopurine-induced leucopenia grades in children with acute lymphoblastic leukemia
SM Naushad, P Dorababu, Y Rupasree… - Cancer Chemotherapy …, 2019 - Springer
Purpose The rationale of the current study was to develop 6-mercaptopurine (6-MP)-
mediated hematological toxicity prediction model for acute lymphoblastic leukemia (ALL) …
mediated hematological toxicity prediction model for acute lymphoblastic leukemia (ALL) …
Frequency of ITPA gene polymorphisms in Iranian patients with acute lymphoblastic leukemia and prediction of its myelosuppressive effects
Mercaptopurine (6-MP) plays an important role in treatment of childhood acute
lymphoblastic leukemia (ALL). Inosine triphosphate pyrophosphohydrolase (ITPA) is an …
lymphoblastic leukemia (ALL). Inosine triphosphate pyrophosphohydrolase (ITPA) is an …