Breaking the loop: oxytocin as a potential treatment for drug addiction

IS McGregor, MT Bowen - Hormones and behavior, 2012 - Elsevier
Drug use typically occurs within a social context, and social factors play an important role in
the initiation, maintenance and recovery from addictions. There is now accumulating …

Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges

X Che, J Cai, Y Liu, T Xu, J Yang, C Wu - Pharmacology & therapeutics, 2021 - Elsevier
Drug addiction is one of the leading causes of mortality worldwide. Despite great advances
were achieved in understanding the neurobiology of drug addiction, the therapeutic options …

Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat

M Frankfurt, K Salas‐Ramirez, E Friedman, V Luine - Synapse, 2011 - Wiley Online Library
Cocaine use during pregnancy induces profound neural and behavioral deficits in both
mother and offspring. The present study was designed to compare the effects of cocaine …

Prenatal and gestational cocaine exposure: Effects on the oxytocin system and social behavior with implications for addiction

SK Williams, JM Johns - Pharmacology Biochemistry and Behavior, 2014 - Elsevier
Drug abuse during pregnancy is a major public health concern, with negative consequences
throughout development. Prenatal cocaine exposure (PCE) in rats produces social behavior …

Prenatal cocaine exposure: the role of cumulative environmental risk and maternal harshness in the development of child internalizing behavior problems in …

RD Eiden, S Godleski, CR Colder… - Neurotoxicology and …, 2014 - Elsevier
This study examined the associations between prenatal exposure to cocaine and other
substances and child internalizing behavior problems at kindergarten. We investigated …

Prenatal substance exposure, early‐life adversity, and parenting: Associations with adolescent stress response

RD Eiden, I Ettekal, J Zhao, MR Kelm… - Developmental …, 2023 - Wiley Online Library
We tested a conceptual model examining associations between prenatal substance
exposure and adolescent cortisol reactivity profiles in response to an acute social evaluative …

Neuronal activity and the expression of hypothalamic oxytocin and vasopressin in social versus cocaine conditioning

C Liu, J Wang, B Zhan, G Cheng - Behavioural brain research, 2016 - Elsevier
Although drug rewards and natural rewards share neural substrates, the neuronal activation
patterns and mechanisms behind the interaction between cocaine and social reward are …

Effects of cocaine on maternal behavior and neurochemistry

BC Nephew, M Febo - Current neuropharmacology, 2012 - ingentaconnect.com
Drug addiction is a chronic relapsing disorder that involves drug seeking and abuse despite
the negative social and health consequences. While the potential effects of cocaine on child …

Cocaine withdrawal influences paternal behavior and associated central expression of vasopressin, oxytocin and tyrosine hydroxylase in mandarin voles

J Wang, F Tai, X Lai - Neuropeptides, 2014 - Elsevier
Although the disruptive effects of cocaine on the maternal care are well known, little is
known about paternal care in the context of cocaine abuse. Vasopressin (AVP), oxytocin …

Early postpartum pup preference is altered by gestational cocaine treatment: Associations with infant cues and oxytocin expression in the MPOA

ETC Lippard, TM Jarrett, MS McMurray… - Behavioural Brain …, 2015 - Elsevier
Cross-fostering studies suggest cocaine-induced deficits in maternal behavior could be
associated with altered behavior of offspring following prenatal cocaine-exposure. Neonatal …