Pulmonary hypertension (PH) is a heterogeneous and fatal disease of the lung vasculature,
where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the …

Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor,
initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism …

Rapid regeneration of smooth muscle after vascular injury is essential for maintaining
arterial function. The existence and putative roles of resident vascular stem cells (VSCs) in …

Abstract Short-term PM 2.5 exposure is related to vascular remodeling and stiffness.
Mitochondria-targeted antioxidant MitoQ is reported to improve the occurrence and …

In lung vascular cells, mitochondria serve a canonical metabolic role, governing energy
homeostasis. In addition, mitochondria exist in dynamic networks, which serve noncanonical …

Pharmacological PPARγ activation improves many hallmarks of PAH, including dysfunction
of BMPR2-PPARγ axis, PAEC, PASMC, EPC, mitochondria/metabolism, and inflammation …

Pulmonary hypertension (PH) represents a group of disorders characterized by elevated
mean pulmonary artery (PA) pressure, progressive right ventricular failure, and often death …

Pulmonary hypertension (PH) is a multi-etiological condition with a similar hemodynamic
clinical sign and end result of right heart failure. Although its causes vary, a similar link …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) exerts pleiotropic effects on
macrophages and is required for self-renewal but the mechanisms responsible are …

Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery smooth muscle
cell (PASMC) dysfunction. However, the underlying mechanisms of PASMC dysfunction …