Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …

Background The mechanism of decreased T cells infiltrating tumor tissues in hepatocellular
carcinoma is poorly understood. Methods Cells were separated from the single‐cell RNA …

Abstract Cellular communication network 2 (CCN2), also known as connective tissue growth
factor (CTGF) regulates diverse cellular processes, some at odds with others, including …

Background: Alzheimer's disease (AD) is a common neurodegenerative disease and mild
cognitive impairment (MCI) is considered as the prodromal stage of AD. Previous studies …

Early pregnancy failure occurs when a mature embryo attaches to an unreceptive
endometrium. During the formation of a receptive endometrium, extracellular vesicles (EVs) …

Background: The potential role of Neurotrophic factor-3 (NTF3) in liver cancer is unknown.
Therefore, we aimed to explore the clinical value of NTF3 in hepatocellular carcinoma …

Background Alzheimer's disease (AD) and glioblastoma are the most common and
devastating diseases in the neurology and neurosurgery departments, respectively. Our …

Brain homeostasis depends on the existence of the blood–brain barrier (BBB). Despite
decades of research, the factors and signalling pathways for modulating and maintaining …

Prostate stromal cells play a crucial role in the promotion of tumor growth and immune
evasion in the tumor microenvironment (TME) through intricate molecular alterations in their …