Macrophage plasticity and atherosclerosis therapy

P Lin, HH Ji, YJ Li, SD Guo - Frontiers in molecular biosciences, 2021 - frontiersin.org
Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity

A Vejux, D Abed-Vieillard, K Hajji, A Zarrouk… - Biochemical …, 2020 - Elsevier
Oxysterols are molecules derived by the oxidation of cholesterol and can be formed either
by auto-oxidation, enzymatically or by both processes. Among the oxysterols formed by auto …

[HTML][HTML] Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy

Y Luo, S Lu, Y Gao, K Yang, D Wu, X Xu, G Sun… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Atherosclerosis-related cardiovascular disease is still the predominant cause of death
worldwide. Araloside C (AsC), a natural saponin, exerts extensive anti-inflammatory …

Macrophage autophagy regulates mitochondria‐mediated apoptosis and inhibits necrotic core formation in vulnerable plaques

Q Xiao, X Che, B Cai, Z Tao, H Zhang… - Journal of cellular …, 2020 - Wiley Online Library
The vulnerable plaque is a key distinguishing feature of atherosclerotic lesions that can
cause acute atherothrombotic vascular disease. This study was designed to explore the …

Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets

CL Galindo, S Khan, X Zhang, YS Yeh… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Lipid-laden foam cells within atherosclerotic plaques are key players in all
phases of lesion development including its progression, necrotic core formation, fibrous cap …

Different approaches in therapy aiming to stabilize an unstable atherosclerotic plaque

M Kowara, A Cudnoch-Jedrzejewska - International Journal of Molecular …, 2021 - mdpi.com
Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to
rupture, which results in atherosclerosis complications—myocardial infarctions and …

Synergistic effects of ginsenoside Rb3 and ferruginol in ischemia-induced myocardial infarction

X Chen, T Liu, Q Wang, H Wang, S Xue… - International Journal of …, 2022 - mdpi.com
Previous research shows that ginsenoside Rb3 (G-Rb3) exhibit significant protective effects
on cardiomyocytes and is considered a promising treatment for myocardial infraction (MI) …

Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome‐Mediated Inflammation and Accelerates Atherosclerosis

R Yuan, W Zhang, P Nie, K Lan, X Yang… - Oxidative Medicine …, 2022 - Wiley Online Library
Purpose. Activation of NLR (nucleotide‐binding and leucine‐rich repeat immune receptor)
family pyrin domain containing 3 (NLRP3) inflammasome mediating interleukin‐(IL‐) 1β …

Untangling the cooperative role of nuclear receptors in cardiovascular physiology and disease

A Paredes, R Santos-Clemente, M Ricote - International Journal of …, 2021 - mdpi.com
The heart is the first organ to acquire its physiological function during development, enabling
it to supply the organism with oxygen and nutrients. Given this early commitment …

Dietary kelp meal improves serum antioxidants, intestinal immunity, and lipid metabolism in hybrid snakehead (Channa maculata ♀ × Channa argus ♂)

S Wang, D Sun, B Ye, G Xu… - … of the Science of Food and …, 2024 - Wiley Online Library
BACKGROUND Dietary kelp possesses a variety of useful biological qualities but does not
have a toxic effect on the host. In this study, we examine how kelp dietary supplementation …