Silk fibroin has applications in different medical fields such as tissue engineering,
regenerative medicine, drug delivery and medical devices. Advances in silk chemistry and …

The covalent immobilisation of enzymes generally involves the use of highly reactive
crosslinkers, such as glutaraldehyde, to couple enzyme molecules to each other or to …

Recent advances in materials science and engineering highlight the importance of
designing sophisticated biomaterials with well-defined architectures and tunable properties …

Hydroxyphenylpyruvate dioxygenase (HPPD) plays a crucial role in the synthesis of
nutrients needed to maintain optimal plant growth. Its level is closely linked to the extent of …

The development of reagents that can selectively react in complex biological media is an
important challenge. Here we show that N1‐alkylation of 1, 2, 4‐triazines yields the …

Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …

Pancreatic cancer is one of the most malignant tumors with the highest mortality rates, and it
currently lacks effective drugs. Aptamer-drug conjugates (ApDC), as a form of nucleic acid …

Due to its simplicity, high efficiency, and chemo-selectivity, bioorthogonal chemistry has
shown a great application potential in pre-targeting. Currently, four bioorthogonal pairs as …

Transition metal catalysts (TMCs), capable of performing bioorthogonal reactions, have
been engineered to trigger the formation of bioactive molecules in a controlled manner for …

Herein, we demonstrate for the first time that noncanonical DNA can direct macrocyclization‐
like challenging reactions to synthesize gene modulators. The planar G‐quartets present in …