Itaconate uptake via SLC13A3 improves hepatic antibacterial innate immunity
Itaconate is an immunoregulatory metabolite produced by the mitochondrial enzyme
immune-responsive gene 1 (IRG1) in inflammatory macrophages. We recently identified an …
immune-responsive gene 1 (IRG1) in inflammatory macrophages. We recently identified an …
[HTML][HTML] Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation
MC Barbalace, M Freschi, I Rinaldi, L Zallocco… - Antioxidants, 2024 - mdpi.com
Neuroinflammation is a critical aspect of various neurodegenerative diseases, such as
Alzheimer's and Parkinson's diseases. This study investigates the anti-neuroinflammatory …
Alzheimer's and Parkinson's diseases. This study investigates the anti-neuroinflammatory …
Itaconate and dimethyl itaconate upregulate IL-6 production in the LPS-induced inflammation in mice
M Nosenko, D Anisov, E Gubernatorova… - Journal of Leukocyte …, 2024 - academic.oup.com
Itaconate is one of the most studied immunometabolites produced by myeloid cells during
inflammatory response. It mediates a wide range of anti-inflammatory and immunoregulatory …
inflammatory response. It mediates a wide range of anti-inflammatory and immunoregulatory …