Binding events of ligands to receptors are the key for an understanding of biological
processes. Gaining insight into protein–protein and protein–ligand interactions in solution …

Protein–ligand interactions are of fundamental importance in almost all processes in living
organisms. The ligands comprise small molecules, drugs or biological macromolecules and …

Abstract Carbohydrate Chemistry and Glycobiology have witnessed a rapid expansion
during the last few years with the development of numerous new, imaginative and efficient …

3.3. 2. Post-acquisition solvent suppression 3.3. 3. Suppression of t2 ridges 3.3. 4. Two-
dimertsional spectral deconvolution 3.4. Nonspecific binding and solvent viscosity effects 4 …

A couple of recent applications of intermolecular NOE (INOE) experiments as applied to
biomolecular systems involve the (i) saturation transfer difference NMR (STD-NMR) method …

This volume covers the new methodological advances in NMR spectroscopy that have been
developed since the publication of the first edition. These include:'indirect …

The theory of the time dependent transferred nuclear Overhauser effect (TRNOE) for the
generalized case of an exchanging system containing multiple spins as applied to a ligand …

In the extreme narrowing limit where co2tc2 «1 (ie, for small molecules having tc» 10~ n
sec),/i (S)= 0.5, which corresponds to a maximum enhancement of 50%. For large …

Development of new drugs often involves the screening of compound libraries for biological
activity. Currently, the biologically active component can only be identified if either a pure …

▪ Abstract The conformation of the ligand in complex with a macromolecular target can be
studied by nuclear magnetic resonance (NMR) in solution for both tightly and weakly forming …