Microneedle system for tissue engineering and regenerative medicines: a smart and efficient therapeutic approach

MUA Khan, MA Aslam, MFB Abdullah, H Gul… - …, 2024 - iopscience.iop.org
The global demand for an enhanced quality of life and extended lifespan has driven
significant advancements in tissue engineering and regenerative medicine. These fields …

[HTML][HTML] Development of dissolving microneedles for intradermal delivery of the long-acting antiretroviral drug bictegravir

C Zhang, LK Vora, IA Tekko, F Volpe-Zanutto… - International journal of …, 2023 - Elsevier
Oral administration and intramuscular (IM) injection are commonly recommended options for
human immunodeficiency virus (HIV) treatment. However, poor patient compliance due to …

Hydrogel-Based Microneedle as a Drug Delivery System

D Filho, M Guerrero, M Pariguana, A Marican… - Pharmaceutics, 2023 - mdpi.com
The skin is considered the largest and most accessible organ in the human body, and allows
the use of noninvasive and efficient strategies for drug administration, such as the …

Gelatin/PVP/hydroxyapatite nanocomposite based on double micro-emulsion for tissue engineering applications

SS Nasiri, M Pourmadadi, A Rahdar… - Journal of Molecular …, 2024 - Elsevier
Biomedical applications of composite hydrogels are attractive because of their
characteristics. Gelatin/poly (vinyl pyrrolidone)(PVP) and HAp nanocomposite hydrogel are …

[HTML][HTML] Risperidone-cyclodextrin complex reservoir combined with hydrogel-forming microneedle array patches for enhanced transdermal delivery

R Ghanma, QK Anjani, YA Naser, AHB Sabri… - European Journal of …, 2024 - Elsevier
Hydrogel-forming microneedle array patches (HFMAPs) are microneedles that create
microconduits upon insertion and swelling in the skin, potentially allowing prolonged drug …

Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic …

CK Enggi, S Sulistiawati, A Himawan… - ACS Biomaterials …, 2024 - ACS Publications
Telmisartan (TEL) is a promising antihypertensive agent among other angiotensin receptor
blockers. However, its oral application is limited by its poor water solubility. This study …

Design and evaluation of dissolvable microneedles for treating atopic dermatitis

N Ben David, Y Richtman, A Gross, R Ibrahim, A Nyska… - Pharmaceutics, 2023 - mdpi.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease caused predominantly by
immune dysregulation. The global impact of AD continues to increase, making it not only a …

Development of Transdermal Formulation Integrating Polymer-Based Solid Microneedles and Thermoresponsive Gel Fucoidan for Antiaging: Proof of Concept Study

F Tangdilintin, AA Achmad, Stephanie, S Sulistiawati… - Langmuir, 2024 - ACS Publications
Skin can be damaged by intense and prolonged exposure to ultraviolet (UV) radiation.
Photoaging and acute damage from sun exposure result in collagen degradation and …

Transdermal delivery of captopril using poly (vinyl pyrrolidone)/poly (vinyl alcohol)-based dissolving and hydrogel-forming microneedles: A proof of concept

D Ramadon, F Muliawardani, NA Nisrina… - European Polymer …, 2024 - Elsevier
Captopril (CAP) is an angiotensin-converting enzyme (ACE) inhibitor that has been widely
used to treat hypertension. Oral administration of CAP has been associated with …

Hispidulin-rich fraction of Clerodendrum fragrans Wild.(Sesewanua) dissolving microneedle as antithrombosis candidate: A proof of concept study

Z Sapiun, AK Imran, SNFS Mohamad, AN Aisyah… - International Journal of …, 2024 - Elsevier
Existing conventional antithrombosis drugs have caused many side effects, opening up
opportunities for the development of new thrombotic drugs. There is potential to use the …