Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

N-glycosylation is one of the most important posttranslational modifications of proteins. It
plays important roles in the biogenesis and functions of proteins by influencing their folding …

Context Estradiol is the primary female sex hormone and plays an important role for skeletal
health in both sexes. Several enzymes are involved in estradiol metabolism, but few …

UGTs play crucial roles in the metabolism and detoxification of both endogenous and
xenobiotic compounds. The key roles of UGTs in human health have garnered great interest …

Human UDP-glucuronosyltransferase enzymes (hUGTs), one of the most important classes
of conjugative enzymes, are responsible for the glucuronidation and detoxification of a …

Estrone, estradiol and estriol are endogenous human estrogens that are rapidly conjugated
with glucuronic acid in both intestinal and hepatic epithelial cells. The resulting …

Background Abnormally changed steroid hormones during pregnancy are closely related to
the pathological process of gestational diabetes mellitus (GDM). Our aim was to …

Abstract UDP-glucuronosyltransferase 1A10 (UGT1A10) is an important phase II human
metabolic enzyme. However, few methods are available to facilely monitor the function of …

The aim of this work was to highlight a considerable and broad problem in UGT1A10 activity
assessment that has led to underestimation of its role in intestinal glucuronidation of drugs …

Serotonin is a UGT1A6 substrate that is mainly found in the extrahepatic tissues where some
UGT1As are expressed. The aim of the present study was to characterize serotonin …