Blessing or curse? Proteomics in granzyme research

LT Joeckel, PI Bird - PROTEOMICS–Clinical Applications, 2014 - Wiley Online Library
Granzymes (gzms) are a group of serine proteases that play an important role in innate and
adaptive immunity, blood coagulation, apoptosis, and inflammation, but are also connected …

[HTML][HTML] HTLV-1 drives vigorous clonal expansion of infected CD8+ T cells in natural infection

A Melamed, DJ Laydon, H Al Khatib, AG Rowan… - Retrovirology, 2015 - Springer
Abstract Background Human T-lymphotropic Virus Type I (HTLV-1) is a retrovirus that
persistently infects 5–10 million individuals worldwide and causes disabling or fatal …

Multiplex real-time PCR for the detection and quantitation of HTLV-1 and HTLV-2 proviral load: addressing the issue of indeterminate HTLV results

A Waters, ALA Oliveira, S Coughlan… - Journal of Clinical …, 2011 - Elsevier
BACKGROUND: Routine diagnosis of Human T Lymphotropic virus (HTLV) infection is
primarily serologically based; however the proportion of unresolved and indeterminate …

[HTML][HTML] Clonality of HTLV-2 in natural infection

A Melamed, AD Witkover, DJ Laydon, R Brown… - PLoS …, 2014 - journals.plos.org
Human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) both cause lifelong
persistent infections, but differ in their clinical outcomes. HTLV-1 infection causes a chronic …

Role of wild-type and recombinant human T-cell leukemia viruses in lymphoproliferative disease in humanized NSG mice

DD Huey, B Bolon, K La Perle, P Kannian… - Comparative …, 2018 - ingentaconnect.com
Chronic infection with human T-cell leukemia virus type 1 (HTLV1) can lead to adult T-cell
leukemia (ATL). In contrast, infection with HTLV2 does not lead to leukemia, potentially …

[HTML][HTML] HTLV-2 Enhances CD8+ T Cell-Mediated HIV-1 Inhibition and Reduces HIV-1 Integrated Proviral Load in People Living with HIV-1

M Abad-Fernández, FJ Hernández-Walias… - Viruses, 2022 - mdpi.com
People living with HIV-1 and HTLV-2 concomitantly show slower CD4+ T cell depletion and
AIDS progression, more frequency of the natural control of HIV-1, and lower mortality rates …

Human T-cell leukemia viruses types 1 and 2

EL Murphy, RL Bruhn - Viral Infections of Humans: Epidemiology and …, 2022 - Springer
Human T-lymphotropic virus (HTLV) is a member of the RNA virus Retroviridae family,
genus Deltaretrovirus, that causes chronic infections of humans and is divided into four …

Human T-cell leukemia virus type 2 (HTLV-2) biology and pathogenesis

R Doueiri, PL Green - Cancer Associated Viruses, 2011 - Springer
Human T-cell leukemia viruses (HTLV) type 1 (HTLV-1) and type 2 (HTLV-2) are highly
related complex retroviruses that have been studied intensely for nearly three decades …

[图书][B] Characterization of the human T-cell leukemia virus type-2 p28 accessory protein

R Doueiri - 2012 - search.proquest.com
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) was the first identified human
retrovirus that causes malignancy, and further research identified it as the etiological agent …

IGHV1-69 as a promising candidate for the development of a shared immunotherapy to B-cell lymphomas

E Muraro - 2013 - research.unipd.it
B-cell Non-Hodgkin Lymphomas (B-NHL) are a heterogeneous group of cancers, broadly
diffused worldwide and often relapsing after standard treatment and rituximab. Therapeutic …