Ketones and the heart: metabolic principles and therapeutic implications

TR Matsuura, P Puchalska, PA Crawford… - Circulation …, 2023 - Am Heart Assoc
The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

[HTML][HTML] Exogenous ketone supplements in athletic contexts: past, present, and future

M Evans, TS McClure, AP Koutnik, B Egan - Sports medicine, 2022 - Springer
The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …

[HTML][HTML] Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities

J Lv, Y Li, S Shi, X Xu, H Wu, B Zhang… - Biomedicine & …, 2022 - Elsevier
Patients with heart failure (HF) usually present with skeletal muscle diseases of varying
severity, ranging from early fatigue on exercise to sarcopenia, sarcopenic obesity or …

A ketogenic diet combined with exercise alters mitochondrial function in human skeletal muscle while improving metabolic health

VJ Miller, RA LaFountain, E Barnhart… - American Journal …, 2020 - journals.physiology.org
Animal data indicate that ketogenic diets are associated with improved mitochondrial
function, but human data are lacking. We aimed to characterize skeletal muscle …

[HTML][HTML] Exogenous ketosis impairs 30-min time-trial performance independent of bicarbonate supplementation

C Poffé, F Wyns, M Ramaekers… - Medicine and science in …, 2021 - ncbi.nlm.nih.gov
Purpose We recently demonstrated that coingestion of NaHCO 3 to counteract ketoacidosis
resulting from oral ketone ester (KE) intake improves mean power output during a 15-min …

Dietary nitrate preserves mitochondrial bioenergetics and mitochondrial protein synthesis rates during short‐term immobilization in mice

HL Petrick, RM Handy, B Vachon… - The Journal of …, 2023 - Wiley Online Library
Skeletal muscle disuse reduces muscle protein synthesis rates and induces atrophy, events
associated with decreased mitochondrial respiration and increased reactive oxygen …

New horizon: exercise and a focus on tissue-brain crosstalk

LK Townsend, REK MacPherson… - The Journal of Clinical …, 2021 - academic.oup.com
The world population is aging, leading to increased rates of neurodegenerative disorders.
Exercise has countless health benefits and has consistently been shown to improve brain …

A practical perspective on how to develop, implement, execute, and reproduce high‐resolution respirometry experiments: The physiologist's guide to an Oroboros O2k

MA Walsh, RV Musci, RA Jacobs… - The FASEB …, 2023 - Wiley Online Library
The development of high‐resolution respirometry (HRR) has greatly expanded the analytical
scope to study mitochondrial respiratory control relative to specific tissue/cell types across …

[HTML][HTML] Adherence to a ketogenic low-carbohydrate, high-fat diet is associated with diminished training quality in elite racewalkers

AKA McKay, MLR Ross, N Tee… - … Journal of Sports …, 2023 - journals.humankinetics.com
Purpose: To examine the effects of a high-carbohydrate diet (HCHO), periodized-
carbohydrate (CHO) diet (PCHO), and ketogenic low-CHO high-fat diet (LCHF) on training …

Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle

TY Huang, MA Linden, SE Fuller… - American Journal …, 2021 - journals.physiology.org
Ketogenic diets (KDs) are reported to improve body weight, fat mass, and exercise
performance in humans. Unfortunately, most rodent studies have used a low-protein KD …