Ketones and the heart: metabolic principles and therapeutic implications
The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …
[HTML][HTML] Exogenous ketone supplements in athletic contexts: past, present, and future
M Evans, TS McClure, AP Koutnik, B Egan - Sports medicine, 2022 - Springer
The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …
[HTML][HTML] Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities
J Lv, Y Li, S Shi, X Xu, H Wu, B Zhang… - Biomedicine & …, 2022 - Elsevier
Patients with heart failure (HF) usually present with skeletal muscle diseases of varying
severity, ranging from early fatigue on exercise to sarcopenia, sarcopenic obesity or …
severity, ranging from early fatigue on exercise to sarcopenia, sarcopenic obesity or …
A ketogenic diet combined with exercise alters mitochondrial function in human skeletal muscle while improving metabolic health
VJ Miller, RA LaFountain, E Barnhart… - American Journal …, 2020 - journals.physiology.org
Animal data indicate that ketogenic diets are associated with improved mitochondrial
function, but human data are lacking. We aimed to characterize skeletal muscle …
function, but human data are lacking. We aimed to characterize skeletal muscle …
[HTML][HTML] Exogenous ketosis impairs 30-min time-trial performance independent of bicarbonate supplementation
C Poffé, F Wyns, M Ramaekers… - Medicine and science in …, 2021 - ncbi.nlm.nih.gov
Purpose We recently demonstrated that coingestion of NaHCO 3 to counteract ketoacidosis
resulting from oral ketone ester (KE) intake improves mean power output during a 15-min …
resulting from oral ketone ester (KE) intake improves mean power output during a 15-min …
Dietary nitrate preserves mitochondrial bioenergetics and mitochondrial protein synthesis rates during short‐term immobilization in mice
HL Petrick, RM Handy, B Vachon… - The Journal of …, 2023 - Wiley Online Library
Skeletal muscle disuse reduces muscle protein synthesis rates and induces atrophy, events
associated with decreased mitochondrial respiration and increased reactive oxygen …
associated with decreased mitochondrial respiration and increased reactive oxygen …
New horizon: exercise and a focus on tissue-brain crosstalk
LK Townsend, REK MacPherson… - The Journal of Clinical …, 2021 - academic.oup.com
The world population is aging, leading to increased rates of neurodegenerative disorders.
Exercise has countless health benefits and has consistently been shown to improve brain …
Exercise has countless health benefits and has consistently been shown to improve brain …
A practical perspective on how to develop, implement, execute, and reproduce high‐resolution respirometry experiments: The physiologist's guide to an Oroboros O2k
The development of high‐resolution respirometry (HRR) has greatly expanded the analytical
scope to study mitochondrial respiratory control relative to specific tissue/cell types across …
scope to study mitochondrial respiratory control relative to specific tissue/cell types across …
[HTML][HTML] Adherence to a ketogenic low-carbohydrate, high-fat diet is associated with diminished training quality in elite racewalkers
AKA McKay, MLR Ross, N Tee… - … Journal of Sports …, 2023 - journals.humankinetics.com
Purpose: To examine the effects of a high-carbohydrate diet (HCHO), periodized-
carbohydrate (CHO) diet (PCHO), and ketogenic low-CHO high-fat diet (LCHF) on training …
carbohydrate (CHO) diet (PCHO), and ketogenic low-CHO high-fat diet (LCHF) on training …
Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle
Ketogenic diets (KDs) are reported to improve body weight, fat mass, and exercise
performance in humans. Unfortunately, most rodent studies have used a low-protein KD …
performance in humans. Unfortunately, most rodent studies have used a low-protein KD …