Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

During vertebrate development, a wide variety of cell types and tissues emerge from a single
fertilized oocyte. One of these tissues, the central nervous system, contains many types of …

Classical lissencephaly is a genetic neurological disorder associated with mental
retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe …

Miller-Dieker syndrome (MDS) is caused by a heterozygous deletion of chromosome 17p13.
3 involving the genes LIS1 and YWHAE (coding for 14.3. 3ε) and leads to malformations …

Idiopathic generalized epilepsies account for 30% of all epilepsies. Despite a predominant
genetic aetiology, the genetic factors predisposing to idiopathic generalized epilepsies …

Abstract Development of a multicellular organism from a fertilized egg depends on a precise
balance between symmetric cell divisions to expand the pool of similar cells, and …

Centrosome amplification is a hallmark of human tumours. In flies, extra centrosomes cause
spindle position defects that result in the expansion of the neural stem cell (NSC) pool and …

Genes disrupted in human microcephaly (meaning" small brain") define key regulators of
neural progenitor proliferation and cell-fate specification. In comparison, genes mutated in …

Neuronal migration is essential for the development of the mammalian brain. Here, we
document severe defects in neuronal migration and reduced numbers of neurons in lamin …

Deletions at 16p13. 11 are associated with schizophrenia, mental retardation, and most
recently idiopathic generalized epilepsy. To evaluate the role of 16p13. 11 deletions, as well …