Monoclonal antibodies can provide important pre-or post-exposure protection against
infectious disease for those not yet vaccinated or in individuals that fail to mount a protective …

Filoviruses such as Ebola virus continue to pose a substantial health risk to humans.
Advances in the sequencing and functional characterization of both pathogen and host …

The fast and untraceable virus mutations take lives of thousands of people before the
immune system can produce the inhibitory antibody. The recent outbreak of COVID-19 …

Remdesivir is a broad-spectrum antiviral nucleotide prodrug that has been clinically
evaluated in Ebola virus patients and recently received emergency use authorization (EUA) …

Antibody escape mutations pose a significant challenge to the effectiveness of vaccines and
antibody-based therapies. The ability to predict these escape mutations with computer …

Ebola virus (EBOV) is a zoonotic virus comprising of six known different species, designated
within the family Filoviridae and genus Ebolavirus. The first recorded outbreak of an EBOV …

Synthetically engineered DNA-encoded monoclonal antibodies (DMAbs) are an in vivo
platform for evaluation and delivery of human mAb to control against infectious disease …

Background Computational methods of predicting protein stability changes upon missense
mutations are invaluable tools in high-throughput studies involving a large number of protein …

Since the modern synthesis, the fitness effects of mutations and epistasis have been central
yet provocative concepts in evolutionary and population genetics. Studies of how the …

De novo mutations in the synaptic GTPase activating protein (SynGAP) are associated with
neurological disorders like intellectual disability, epilepsy, and autism. SynGAP is also …