Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and
Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i …

Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …

Background G-rich sequences undergo unique structural equilibria to form G-quadruplexes
(G4) both in vitro and in cell systems. Several pathologies emerged to be directly related to …

Nucleophosmin is a highly and ubiquitously expressed protein, mainly localized in nucleoli
but able to shuttle between nucleus and cytoplasm. Nucleophosmin plays crucial roles in …

Nucleophosmin (NPM1) is a mainly nucleolar protein that shuttles between nucleoli,
nucleoplasm and cytoplasm to fulfill its many functions. It is a chaperone of both nucleic …

Loss of telomeres stability is a hallmark of cancer cells. Exposed telomeres are prone to
aberrant end-joining reactions leading to chromosomal fusions and translocations. Human …

Recombinant adeno-associated virus (rAAV) is one of the prominent gene delivery vehicles
that has opened promising opportunities for novel gene therapeutic approaches. However …

The DNA methyltransferase enzymes (DNMT s) catalyzing cytosine methylation do so at
specific locations of the genome, although with some level of redundancy. The de novo …

Acute myeloid leukemia (AML) is a clinically and a molecularly heterogeneous disease
characterized by the accumulation of undifferentiated and uncontrolled proliferation of …

ABSTRACT Nucleophosmin (NPM)‐1 is a multifunctional protein involved in a variety of
biologic processes and has been implicated in the pathogenesis of several human …