Importance Early treatment initiation in multiple sclerosis (MS) is crucial in preventing
irreversible neurological damage and disability progression. The current assessment of …

Introduction In multiple sclerosis (MS), paramagnetic rim lesions (PRLs) on MRI identify a
subset of chronic active lesions (CALs), which have been linked through clinical and …

In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on
magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports …

BACKGROUND AND PURPOSE: Previous studies have suggested that the central vein sign
and iron rims are specific features of MS lesions. Using 3T SWI, we aimed to compare the …

Background: The central vein sign (CVS) is a radiological feature proposed as a multiple
sclerosis (MS) imaging biomarker able to accurately differentiate MS from other white matter …

Background and Objectives The central vein sign (CVS), a central linear hypointensity within
lesions on T2*-weighted imaging, has been established as a sensitive and specific …

Objective: The central vein sign (CVS) and “paramagnetic rim lesions”(PRL) are emerging
imaging biomarkers in multiple sclerosis (MS) reflecting perivenular demyelination and …

The central vein sign (CVS) is an efficient imaging biomarker for multiple sclerosis (MS)
diagnosis, but its application in clinical routine is limited by inter‐rater variability and the …

Axonal loss in multiple sclerosis (MS) is a key component of disease progression and
permanent neurologic disability. MS is a heterogeneous demyelinating and …

Focal lesions in both white and gray matter are characteristic of multiple sclerosis (MS).
Histopathological studies have helped define the main underlying pathological processes …