Recent understanding of human milk oligosaccharides in establishing infant gut microbiome and roles in immune system

RP Singh, J Niharika, KK Kondepudi, M Bishnoi… - Food Research …, 2022 - Elsevier
Human milk oligosaccharides (HMOs) are complex sugars with distinctive structural diversity
present in breast milk. HMOs have various functional roles to play in infant development …

Human milk oligosaccharides and the infant gut microbiome from an eco-evolutionary perspective

S Kijner, O Kolodny, M Yassour - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•HMOs are unique complex sugars found in breastmilk, however infants can't
digest them.•Gut microbes can utilize HMOs, thus, breastfeeding shapes the infant …

Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants

A Wang, A Diana, S Rahmannia, RS Gibson… - Gut …, 2023 - Taylor & Francis
Maternal secretor status has been shown to be associated with the presence of specific
fucosylated human milk oligosaccharides (HMOs), and the impact of maternal secretor …

[PDF][PDF] Summary of the joint National Institutes of Health and the Food and Drug Administration workshop titled “exploring the science surrounding the safe use of …

SM Donovan, SA Abrams, MB Azad, MB Belfort… - The Journal of …, 2023 - Elsevier
The US government and many professional societies recommend that human milk be the
sole source of nutrition for infants up to 6 months-of-age.(1, 2) However, only about 25% of …

Weighted analysis of 2′-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, 3′-sialyllactose, and 6′-sialyllactose concentrations in human milk

DB Conze, CL Kruger, JM Symonds, R Lodder… - Food and Chemical …, 2022 - Elsevier
Over 150 human milk oligosaccharides (HMOs) have been identified and their
concentrations in human milk vary depending on Secretor and Lewis blood group status …

Exploring human milk dynamics: Interindividual variation in milk proteome, peptidome, and metabolome

PM Dekker, S Boeren, JB Van Goudoever… - Journal of proteome …, 2022 - ACS Publications
Human milk is a dynamic biofluid, and its detailed composition receives increasing attention.
While most studies focus on changes over time or differences between maternal …

NMR metabonomic profile of preterm human milk in the first month of lactation: from extreme to moderate prematurity

C Peila, S Sottemano, F Cesare Marincola… - Foods, 2022 - mdpi.com
Understanding the composition of human milk (HM) can provide important insights into the
links between infant nutrition, health, and development. In the present work, we have …

Human milk oligosaccharides: a comprehensive review towards metabolomics

L Corona, A Lussu, A Bosco, R Pintus… - Children, 2021 - mdpi.com
Human milk oligosaccharides (HMOs) are the third most represented component in breast
milk. They serve not only as prebiotics but they exert a protective role against some …

[HTML][HTML] From mother's milk to structural insights: 1H–15N NMR analysis of Lewis X antigen-bearing oligosaccharides isolated from human milk

Z Garádi, A Dancsó, V Piskarev, S Béni - Carbohydrate Polymers, 2025 - Elsevier
Human milk oligosaccharides (HMOs) are complex unconjugated glycans abundant in
breast milk, with vital roles in infant nutrition and health. The structural elucidation of HMOs …

[HTML][HTML] Modifiable and Non-Modifiable Factors That Affect Human Milk Oligosaccharides Composition

M Konieczna, A Koryszewska-Bagińska… - Nutrients, 2024 - mdpi.com
Human milk, the gold standard in infant nutrition, is a unique fluid that provides essential
nutrients such as lactose, lipids, proteins, and free oligosaccharides. While its primary role is …