A guide into glycosciences: how chemistry, biochemistry and biology cooperate to crack the sugar code
D Solis, NV Bovin, AP Davis, J Jiménez-Barbero… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Background The most demanding challenge in research on molecular aspects within the
flow of biological information is posed by the complex carbohydrates (glycan part of cellular …
flow of biological information is posed by the complex carbohydrates (glycan part of cellular …
[HTML][HTML] Sialylated glycan bindings from SARS-CoV-2 spike protein to blood and endothelial cells govern the severe morbidities of COVID-19
DE Scheim, P Vottero, AD Santin, AG Hirsh - International journal of …, 2023 - mdpi.com
Consistent with well-established biochemical properties of coronaviruses, sialylated glycan
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …
[HTML][HTML] Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
New broad and potent neutralizing HIV-1 antibodies have recently been described that are
largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 …
largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 …
[HTML][HTML] Recent H3N2 viruses have evolved specificity for extended, branched human-type receptors, conferring potential for increased avidity
Human and avian influenza viruses recognize different sialic acid-containing receptors,
referred to as human-type (NeuAcα2-6Gal) and avian-type (NeuAcα2-3Gal), respectively …
referred to as human-type (NeuAcα2-6Gal) and avian-type (NeuAcα2-3Gal), respectively …
[HTML][HTML] Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection
T Walther, R Karamanska, RWY Chan… - PLoS …, 2013 - journals.plos.org
The first step in influenza infection of the human respiratory tract is binding of the virus to
sialic (Sia) acid terminated receptors. The binding of different strains of virus for the receptor …
sialic (Sia) acid terminated receptors. The binding of different strains of virus for the receptor …
[HTML][HTML] N-glycolylneuraminic acid as a receptor for influenza A viruses
A species barrier for the influenza A virus is the differential expression of sialic acid, which
can either be α2, 3-linked for avians or α2, 6-linked for human viruses. The influenza A virus …
can either be α2, 3-linked for avians or α2, 6-linked for human viruses. The influenza A virus …
[HTML][HTML] A homogeneous high-throughput array for the detection and discrimination of influenza A viruses
The transmission of influenza A viruses (IAVs) from animal to human has resulted in a
number of pandemics. Here, we report the synthesis of several sialyl-glycan-functionalized …
number of pandemics. Here, we report the synthesis of several sialyl-glycan-functionalized …
[HTML][HTML] The human lung glycome reveals novel glycan ligands for influenza A virus
Glycans within human lungs are recognized by many pathogens such as influenza A virus
(IAV), yet little is known about their structures. Here we present the first analysis of the N-and …
(IAV), yet little is known about their structures. Here we present the first analysis of the N-and …
[HTML][HTML] Human H3N2 influenza viruses isolated from 1968 to 2012 show varying preference for receptor substructures with no apparent consequences for disease or …
S Gulati, DF Smith, RD Cummings, RB Couch… - PloS one, 2013 - journals.plos.org
It is generally accepted that human influenza viruses bind glycans containing sialic acid
linked α2–6 to the next sugar, that avian influenza viruses bind glycans containing the α2–3 …
linked α2–6 to the next sugar, that avian influenza viruses bind glycans containing the α2–3 …
[HTML][HTML] Structure and receptor binding preferences of recombinant human A (H3N2) virus hemagglutinins
H Yang, PJ Carney, JC Chang, Z Guo, JM Villanueva… - Virology, 2015 - Elsevier
Abstract A (H3N2) influenza viruses have circulated in humans since 1968, and antigenic
drift of the hemagglutinin (HA) protein continues to be a driving force that allows the virus to …
drift of the hemagglutinin (HA) protein continues to be a driving force that allows the virus to …