[HTML][HTML] Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
WNT as a driver and dependency in cancer
The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
[HTML][HTML] LRP5 and LRP6 in Wnt signaling: similarity and divergence
Q Ren, J Chen, Y Liu - Frontiers in cell and developmental biology, 2021 - frontiersin.org
The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic
development, injury repair and the pathogenesis of human diseases. In vertebrates, low …
development, injury repair and the pathogenesis of human diseases. In vertebrates, low …
Wnt signalling: conquering complexity
KE Wiese, R Nusse, R van Amerongen - Development, 2018 - journals.biologists.com
The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs,
zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the …
zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the …
Wnt signaling and drug resistance in cancer
Z Zhong, DM Virshup - Molecular pharmacology, 2020 - ASPET
Wnts are secreted proteins that bind to cell surface receptors to activate downstream
signaling cascades. Normal Wnt signaling plays key roles in embryonic development and …
signaling cascades. Normal Wnt signaling plays key roles in embryonic development and …
[HTML][HTML] Wnt/Beta-catenin signaling regulation and a role for biomolecular condensates
KN Schaefer, M Peifer - Developmental cell, 2019 - cell.com
Wnt/β-Catenin signaling plays key roles in tissue homeostasis and cell fate decisions in
embryonic and post-embryonic development across the animal kingdom. As a result …
embryonic and post-embryonic development across the animal kingdom. As a result …
Wnt/β‐catenin signaling: Structure, assembly and endocytosis of the signalosome
Wnt/β‐catenin signaling is an ancient pathway that regulates key aspects of embryonic
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …
Aberrant Cholesterol Metabolism and Wnt/β‐Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth
S Zheng, J Lin, Z Pang, H Zhang, Y Wang… - Advanced …, 2022 - Wiley Online Library
Abstract Frizzled (Fzd) proteins are Wnt receptors and play essential roles in development,
homeostasis, and oncogenesis. How Wnt/Fzd signaling is coupled to physiological …
homeostasis, and oncogenesis. How Wnt/Fzd signaling is coupled to physiological …
The evolution of two-dimensional gel electrophoresis-from proteomics to emerging alternative applications
Abstract Two-dimensional gel electrophoresis (2-DE) is a technique that has been widely
applied in a variety of proteomics studies. It is capable of resolving complex protein mixtures …
applied in a variety of proteomics studies. It is capable of resolving complex protein mixtures …
Wnt/β-catenin signaling inhibitors
X Zhang, N Dong, X Hu - Current topics in medicinal chemistry, 2023 - ingentaconnect.com
The Wnt/β-catenin signaling pathway plays a crucial role in the development, tissue
homeostasis, angiogenesis, and carcinogenesis of cancer. Mutations and excessive …
homeostasis, angiogenesis, and carcinogenesis of cancer. Mutations and excessive …