NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …

Significance: Protein neddylation is catalyzed by an E1 NEDD8-activating enzyme (NAE), an
E2 NEDD8-conjugating enzyme, and an E3 NEDD8 ligase. Known physiological substrates …

Mutations in PINK1 (PTEN-induced putative kinase 1) cause early onset familial Parkinson's
disease (PD). PINK1 accumulates on the outer membrane of damaged mitochondria …

Aging is the biggest risk factor for the development of Alzheimer's disease (AD). Here, we
performed a whole-genome CRISPR screen to identify regulators of neuronal age and show …

Parkinson's disease is caused by a complex interplay of genetic and environmental factors.
Although a number of independent molecular pathways and processes have been …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Protein expression abnormalities have been implicated in the pathophysiology of
schizophrenia, but the underlying cause of these changes is not known. We sought to …

Disarrangement in functions and quality control of mitochondria at synapses are early
events in Alzheimer's disease (AD) pathobiology. We reported that a 20–22 kDa NH2-tau …

Besides abstinence, no effective treatment exists for alcohol-related liver disease (ALD), a
dreaded consequence of alcohol abuse. In this study, we assessed the roles on ALD of dual …

CD36 has been associated with obesity and diabetes in human liver diseases, however, its
role in age-associated nonalcoholic fatty liver disease (NAFLD) is unknown. Therefore, liver …