A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

The vascular endothelial growth factor (VEGF) family, the regulator of blood and lymphatic
vessels, is mostly investigated in the tumor and ophthalmic field. However, the functions it …

Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Human cells have to deal with the constant production of reactive oxygen species (ROS).
Although ROS overproduction might be harmful to cell biology, there are plenty of data …

Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western
countries. Notably, it has a rapidly rising prevalence in China. The patients, commonly …

Angiogenesis, the growth of new blood vessels, is essential in the pathogenesis of joint
inflammatory disorders such as rheumatoid arthritis (RA) and osteoarthritis (OA), facilitating …

Background Salvia miltiorrhiza (SM), one of the frequently used herbs in traditional Chinese
medicine (TCM), has now attracted rising interests for a possible alternative in the …

Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …

Diabetes mellitus may lead to intervertebral disc degeneration (IVDD). Matrix
metalloproteinase‐13 (MMP‐13) is one of the major catabolic factors in extracellular matrix …

A major precursor of advanced glycation end-products (AGEs)-methylglyoxal (MG)-is a
reactive carbonyl metabolite that originates from glycolytic pathways. MG formation and …