Memory consolidation involves transcriptional control of genes in neurons to stabilize a
newly formed memory. Following retrieval, a once consolidated memory destabilizes and …

Since its rediscovery at the beginning of the 21st Century, memory reconsolidation has been
proposed to be a therapeutic target for reducing the impact of emotional memories that can …

Numerous studies have suggested that memories “destabilize” and require de novo protein
synthesis in order to reconsolidate following retrieval, but very little is known about how this …

Repeated drug use has long-lasting effects on plasticity throughout the brain's reward and
memory systems. Environmental cues that are associated with drugs of abuse can elicit …

The persistence of drug memory contributes to relapse to drug seeking. The association
between repeated drug exposure and drug-related cues leads to cravings triggered by drug …

Addiction is a chronic, relapsing disorder. The progression to pathological drug-seeking is
thought to be driven by maladaptive learning processes which store and maintain …

Natural and drug rewards act on the same neural pathway, the mesolimbic dopaminergic
system. In brain regions such as the nucleus accumbens and ventral tegmental area, drugs …

Risk of relapse is a major challenge in the treatment of substance use disorders. Several
types of learning and memory mechanisms are involved in substance use and have …

Memory reconsolidation is a protein synthesis-dependent process that preserves, in some
form, memories that have been destabilized through recall. Reconsolidation is a nearly …

Drug addiction can be seen as a disorder of maladaptive learning characterized by relapse.
Therefore, disrupting drug-related memories could be an approach to improving therapies …