Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to
acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal …

Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body's metabolic reactions and can react with and damage …

Ethanol-induced oxidative stress seems to play a major role in mechanisms by which
ethanol causes liver injury. Many pathways have been suggested to contribute to the ability …

BACKGROUND & AIMS: Alcohol abuse is a major cause of liver injury. The pathologic
features of alcoholic liver disease develop over prolonged periods, yet the cellular defense …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

BACKGROUND Alcohol-associated liver disease (ALD) is a leading cause of liver-related
morbidity and mortality, but there are no therapeutic targets and modalities to prevent ALD …

Patients with alcoholic liver disease frequently exhibit iron overload in association with
increased hepatic fibrosis. Even moderate alcohol consumption elevates body iron stores; …

Background & Aims As a nicotinamide adenine dinucleotide-dependent deacetylase and a
key epigenetic regulator, sirtuin 6 (SIRT6) has been implicated in the regulation of …

Background and Purpose Regulating P2X7 receptor‐mediated activation of NLRP3
inflammasomes could be a therapeutic strategy to treat alcoholic hepatosteatosis. We …

Akt kinase isoforms (Akt1, Akt2, and Akt3) have generally been thought to play overlapping
roles in phosphoinositide 3-kinase (PI3K)-mediated-signaling. However, recent studies have …