Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

Cardiolipin (CL) is a tetra-acylated diphosphatidylglycerol lipid. In physiological conditions,
CL presents unsaturated chains and is located in the inner mitochondria membrane (IMM) …

Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …

Parkinson's disease (PD) is the most common neurological movement disorder
characterized by the selective and irreversible loss of dopaminergic neurons in substantia …

Prolonged exposure to glucocorticoids, the main stress hormones, damages the brain and is
a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid …

Mitochondria, long viewed solely in the context of bioenergetics, are increasingly emerging
as critical hubs for intracellular signaling. Due to their bacterial origin, mitochondria possess …

Abnormal tau protein aggregation in the brain is a hallmark of tauopathies, such as
frontotemporal lobar degeneration and Alzheimer's disease. Substantial evidence has been …

Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Tau misfolding and assembly is linked to a number of neurodegenerative diseases
collectively described as tauopathies, including Alzheimer's disease (AD) and Parkinson's …