Similar to chronic pain, chronic itch is frequently linked to neural sensitization, a
phenomenon wherein the nervous system becomes hypersensitive to stimuli. This process …

Chronic pain is a global problem affecting up to 20% of the world's population and has a
significant economic, social and personal cost to society. Sensory neurons of the dorsal root …

Objectives: The hallmark of sickle cell disease (SCD) is acute and chronic pain, and the pain
dominates the clinical characteristics of SCD patients. Although pharmacological treatments …

Sickle cell disease (SCD) is one of the most common severe genetic diseases around the
world. A majority of SCD patients experience intense pain, leading to hospitalization, and …

Evidence supports, but is inconclusive that sensitization contributes to chronic pain in some
adults with sickle cell disease (SCD). We determined the prevalence of pain sensitization …

Pain in Sickle Cell Disease (SCD) is a major comorbidity and unique with acute pain due to
recurrent and episodic vaso-occlusive crises as well as chronic pain, which can span an …

TRPV1 mediates pain occurring during sickling episodes in sickle cell disease (SCD). We
examined if hemin, a porphyrin released during intravascular hemolysis modulates TRPV1 …

Introduction: Acute pain from episodic vaso-occlusion (VOC) spans the lifespan of almost
everyone with sickle cell disease (SCD), while additional chronic pain develops in …

Debilitating pain affects the lives of patients with sickle cell disease (SCD). Current pain
treatment for patients with SCD fail to completely resolve acute or chronic SCD pain …

Purpose of review As fields such as neurotoxicity evaluation and neuro-related drug
research are increasing in popularity, there is a demand for the expansion of neurotoxicity …