Obesity-induced neuroinflammation: beyond the hypothalamus

O Guillemot-Legris, GG Muccioli - Trends in neurosciences, 2017 - cell.com
Obesity is now a worldwide health issue. Far from being limited to weight gain, obesity is
generally associated with low-grade inflammation and with a cluster of disorders collectively …

Impact of metabolic syndrome on neuroinflammation and the blood–brain barrier

P Van Dyken, B Lacoste - Frontiers in neuroscience, 2018 - frontiersin.org
Metabolic syndrome, which includes diabetes and obesity, is one of the most widespread
medical conditions. It induces systemic inflammation, causing far reaching effects on the …

Oxidative stress in obesity: a critical component in human diseases

L Marseglia, S Manti, G D'Angelo, A Nicotera… - International journal of …, 2014 - mdpi.com
Obesity, a social problem worldwide, is characterized by an increase in body weight that
results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and …

Obesity and neuroinflammation: a pathway to cognitive impairment

AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer

M Matsuda, I Shimomura - Obesity research & clinical practice, 2013 - Elsevier
Obesity, especially of the abdominal type, is a health problem that constitutes metabolic
syndrome and increases the incidence of various diseases, including diabetes …

Insulin resistance and oxidative stress in the brain: what's new?

M Maciejczyk, E Żebrowska, A Chabowski - International journal of …, 2019 - mdpi.com
The latest studies have indicated a strong relationship between systemic insulin resistance
(IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment …

Immune system to brain signaling: neuropsychopharmacological implications

L Capuron, AH Miller - Pharmacology & therapeutics, 2011 - Elsevier
There has been an explosion in our knowledge of the pathways and mechanisms by which
the immune system can influence the brain and behavior. In the context of inflammation, pro …

The longer-term impacts of Western diet on human cognition and the brain

H Francis, R Stevenson - Appetite, 2013 - Elsevier
Animal work over the last three decades has generated a convincing body of evidence that a
Western diet–one high in saturated fat and refined carbohydrates (HFS diet)–can damage …

The obese brain: mechanisms of systemic and local inflammation, and interventions to reverse the cognitive deficit

V Salas-Venegas, RP Flores-Torres… - Frontiers in Integrative …, 2022 - frontiersin.org
Overweight and obesity are now considered a worldwide pandemic and a growing public
health problem with severe economic and social consequences. Adipose tissue is an organ …

Saturated long‐chain fatty acids activate inflammatory signaling in astrocytes

S Gupta, AG Knight, S Gupta, JN Keller… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 1060–1071. Abstract This study describes the effects of long‐
chain fatty acids on inflammatory signaling in cultured astrocytes. Data show that the …