Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …

Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …

In response to energy and nutrient shortage, the liver triggers several catabolic processes to
promote survival. Despite recent progress, the precise molecular mechanisms regulating the …

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by
dietary, environmental, and genetic factors. While the incidence of IBD is increasing …

Bile acids (BAs) function as detergents promoting nutrient absorption and as hormones
regulating nutrient metabolism. Most BAs are key regulatory factors of physiological …

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and
gene-by-environment interactions, rendering the study of underlying mechanisms …

Gut microbiota rearrangement induced by cold temperature is crucial for browning in murine
white adipose tissue. This study provides evidence that DUSP6, a host factor, plays a critical …

Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic
disorders worldwide and is a strong contributor for a broad range of comorbidities, including …

The gut microbiota has a significant impact on the development and function of intestinal
epithelial cells (IECs) by modifying bile acid (BA) metabolites. Recently, specific gut …

Introduction Chemoresistance is a major barrier in the treatment of colorectal cancer (CRC)
and many other cancers. ENO1 has been associated with various biological characteristics …