Astrocytes represent the reticular part of the central nervous system; gap junctions formed by
connexins Cx43, Cx30-and Cx26 provide for homocellular astrocyte-astrocyte coupling …

Generation of relevant and robust models for neurological disorders is of main importance
for both target identification and drug discovery. The non-cell autonomous effects of glial …

Neuropathic pain is a chronic debilitating condition caused by nerve injury or a variety of
diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the …

Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate
cognitive symptoms in Alzheimer's disease (AD). Beyond the widely described neuronal …

This study aimed to demonstrate the potential benefits of donepezil (DPZ) and vitamin D (Vit
D) in combination to counteract the neurodegenerative disorders induced by CuSO4 intake …

Translational methods are needed to monitor the impact of the Alzheimer's disease (AD) and
therapies on brain function in animal models and patients. The formation of amyloid plaques …

Central nervous system disorders remain the leading causes of mortality and morbidity
worldwide, affecting more than 1 billion patients. This therapeutic area suffers from high …

Combination therapy has birthed improved treatment possibilities for a number of complex
and degenerative diseases in the world, which include cancer, diabetes and cardiovascular …

Alzheimer's disease (AD) is a devastating neurodegenerative disease that affects millions of
older people worldwide and is characterized by a progressive deterioration of cognitive …

Background: There is an urgent need to understand and reverse cognitive impairment. The
lack of appropriate animal models combined with the limited knowledge of …