Spatiotemporal omics for biology and medicine

L Liu, A Chen, Y Li, J Mulder, H Heyn, X Xu - Cell, 2024 - cell.com
The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …

Identification of constrained sequence elements across 239 primate genomes

LFK Kuderna, JC Ulirsch, S Rashid, M Ameen… - Nature, 2024 - nature.com
Noncoding DNA is central to our understanding of human gene regulation and complex
diseases,, and measuring the evolutionary sequence constraint can establish the functional …

[HTML][HTML] Deciphering the role of structural variation in human evolution: a functional perspective

C Karageorgiou, O Gokcumen, MY Dennis - Current opinion in genetics & …, 2024 - Elsevier
Advances in sequencing technologies have enabled the comparison of high-quality
genomes of diverse primate species, revealing vast amounts of divergence due to structural …

The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression

Q Wang, KM Clark, R Tiwari, N Raju, GK Tharp… - Cell, 2024 - cell.com
While CD4+ T cell depletion is key to disease progression in people living with HIV and SIV-
infected macaques, the mechanisms underlying this depletion remain incompletely …

Vocal labeling of others by nonhuman primates

G Oren, A Shapira, R Lifshitz, E Vinepinsky, R Cohen… - Science, 2024 - science.org
Humans, dolphins, and elephants are the only known species that vocally label their
conspecifics. It remains unclear whether nonhuman primates share this ability. We recorded …

A hybrid genome assembly of the endangered aye-aye (Daubentonia madagascariensis)

CJ Versoza, SP Pfeifer - G3: Genes, Genomes, Genetics, 2024 - academic.oup.com
The aye-aye (Daubentonia madagascariensis) is the only extant member of the
Daubentoniidae primate family. Although several reference genomes exist for this …

Complete sequencing of ape genomes

DA Yoo, A Rhie, P Hebbar, F Antonacci… - BioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
We present haplotype-resolved reference genomes and comparative analyses of six ape
species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan …

[PDF][PDF] Integrative omics reveals rapidly evolving regulatory sequences driving primate brain evolution

XL Zhuang, JJ Zhang, Y Shao, Y Ye… - Molecular Biology …, 2023 - academic.oup.com
Although the continual expansion of the brain during primate evolution accounts for our
enhanced cognitive capabilities, the drivers of brain evolution have scarcely been explored …

Discovering fragile clades and causal sequences in phylogenomics by evolutionary sparse learning

S Sharma, S Kumar - Molecular Biology and Evolution, 2024 - academic.oup.com
Phylogenomic analyses of long sequences, consisting of many genes and genomic
segments, reconstruct organismal relationships with high statistical confidence. But, inferred …

Complex evolutionary history with extensive ancestral gene flow in an African primate radiation

A Jensen, F Swift, D de Vries, RMD Beck… - Molecular biology …, 2023 - academic.oup.com
Understanding the drivers of speciation is fundamental in evolutionary biology, and recent
studies highlight hybridization as an important evolutionary force. Using whole-genome …