The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …

In vitro liver cell culture models are gaining increasing importance in pharmacological and
toxicological research. The source of cells used is critical for the relevance and the …

The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …

Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and
constitutes one of the most important reasons for the termination of promising drug …

Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly
because of its ability to present with a variety of phenotypes including that of autoimmune …

Liver is a central nexus integrating metabolic and immunologic homeostasis in the human
body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of …

Drug-induced liver injury (DILI) is the major reason for failures in drug development and
withdrawal of approved drugs from the market. Two-dimensional cultures of hepatocytes …

Novel onion-like and multi-layered tubular cellulose hydrogels were constructed, for the first
time, from the cellulose solution in a 7% NaOH/12% urea aqueous solvent by changing the …