Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: the paradigm of radiotherapy

S Logotheti, A Pavlopoulou, HK Rudsari… - Pharmacology & …, 2024 - Elsevier
Advances in cancer therapeutics have improved patient survival rates. However, cancer
survivors may suffer from adverse events either at the time of therapy or later in life …

Cardiac ageing: from hallmarks to therapeutic opportunities

MH Hastings, Q Zhou, C Wu, P Shabani… - Cardiovascular …, 2024 - academic.oup.com
Cardiac ageing is an intricate and multifaceted process with considerable impact on public
health, especially given the global demographic shift towards aged populations. This review …

Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction

T Szabados, A Makkos, B Ágg… - British Journal of …, 2024 - Wiley Online Library
Background and purpose MicroRNA (miRNA) therapy is a promising approach to induce
cardioprotection. We have previously identified cardiac microRNA‐125b*(microRNA‐125b …

[HTML][HTML] Activins and Inhibins in Cardiovascular Pathophysiology

W Tang, Z Gu, J Guo, M Lin, H Tao, D Jia, P Jia - Biomolecules, 2024 - mdpi.com
Activins and inhibins, members of the transforming growth factor β (TGFβ) superfamily, were
initially recognized for their opposing effects on the secretion of follicle-stimulating hormone …

Prognostic Significance of Proteomics‐Discovered Circulating Inflammatory Biomarkers in Patients With Pulmonary Arterial Hypertension

T Yokokawa, O Boucherat, S Martineau… - Journal of the …, 2024 - Am Heart Assoc
Background Pulmonary arterial hypertension (PAH) ultimately leads to right ventricular
failure and premature death. The identification of circulating biomarkers with prognostic …

Immune Markers, Blood Pressure Severity, and Cardiac Remodeling 1 to 2 Years After Hypertensive Disorders of Pregnancy

A Koczo, A Hauspurg, ME Countouris… - Journal of the …, 2023 - Am Heart Assoc
Background Cardiovascular dysfunction and hypertension can persist postpartum following
hypertensive disorders of pregnancy (HDPs). This study hypothesized that activin A …

Molecular remodeling in comorbidities associated with heart failure: a current update

S Appunni, M Rubens, V Ramamoorthy… - Molecular biology …, 2024 - Springer
Recent advances in genomics and proteomics have helped in understanding the molecular
mechanisms and pathways of comorbidities and heart failure. In this narrative review, we …

Defining the cardiac fibroblast secretome in the healthy and infarcted mouse heart

J Bahr, G Poschmann, A Jungmann, M Busch, Z Ding… - bioRxiv, 2024 - biorxiv.org
Cardiac fibroblasts (CF) are key players after myocardial infarction (MI), but their signaling is
only incompletely understood. Here we report a first secretome atlas of CF in control (cCF) …

[PDF][PDF] Quantitative secretome analysis of cardiac fibroblasts in the control heart and after myocardial infarction

J Bahr - 2024 - docserv.uni-duesseldorf.de
Myocardial infarction (MI) is still the leading cause of death worldwide. Especially cardiac
fibrosis, which mediates myocardial stiffness and impairs cardiac function resulting in heart …