Recent advances and challenges in cancer immunotherapy

C Peterson, N Denlinger, Y Yang - Cancers, 2022 - mdpi.com
Simple Summary Immunotherapy helps a person's immune system to target tumor cells.
Recent advances in cancer immunotherapy, including immune checkpoint inhibition …

[HTML][HTML] Myeloid derived suppressor cells in tumor microenvironment: Interaction with innate lymphoid cells

N Tumino, PF Fiore, A Pelosi, L Moretta… - Seminars in Immunology, 2022 - Elsevier
Human myeloid-derived suppressor cells (MDSC) represent a stage of immature myeloid
cells and two main subsets can be identified: monocytic and polymorphonuclear. MDSC …

Molecular imaging of innate immunity and immunotherapy

W Xia, N Singh, S Goel, S Shi - Advanced Drug Delivery Reviews, 2023 - Elsevier
The innate immune system plays a key role as the first line of defense in various human
diseases including cancer, cardiovascular and inflammatory diseases. In contrast to tissue …

Neutrophils in Cancer and potential therapeutic strategies using neutrophil-derived exosomes

A Dutta, S Bhagat, S Paul, JP Katz, D Sengupta… - Vaccines, 2023 - mdpi.com
Neutrophils are the most abundant immune cells and make up about 70% of white blood
cells in human blood and play a critical role as the first line of defense in the innate immune …

Significance of neutrophil to lymphocyte ratio as a predictor of outcome in head and neck cancer treated with definitive chemoradiation

J Kaźmierska, T Bajon, T Winiecki… - Reports of Practical …, 2023 - journals.viamedica.pl
Background: The role o fh ost immune system in carcinogenesis and response to treatment
is increasingly studied, including predictive potential of circulating neutrophils and …

The intratumour microbiota and neutrophilic inflammation in squamous cell vulvar carcinoma microenvironment

N Rustetska, M Szczepaniak, K Goryca… - Journal of Translational …, 2023 - Springer
Background A causal link between microbiota composition (dysbiosis) and oncogenesis has
been demonstrated for several types of cancer. Neutrophils play a role in both immune …

Monitoring Blood Immune Cells in Patients with Advanced Small Cell Lung Cancer Undergoing a Combined Immune Checkpoint Inhibitor/Chemotherapy

D Riemann, S Turzer, G Ganchev, W Schütte, B Seliger… - Biomolecules, 2023 - mdpi.com
In this exploratory prospective observational study on 40 small cell lung cancer (SCLC)
patients treated with a combination of chemotherapy and immune checkpoint inhibitors …

Exosomes‐mediated crosstalk between glioma and immune cells in the tumor microenvironment

X Guo, R Sui, H Piao - CNS Neuroscience & Therapeutics, 2023 - Wiley Online Library
Gliomas are the most common primary malignant tumors in the central nervous system.
However, conventional treatments, such as surgical resection and postoperative combined …

High Neutrophil-to-Lymphocyte Ratio Facilitates Cancer Growth—Currently Marketed Drugs Tadalafil, Isotretinoin, Colchicine, and Omega-3 to Reduce It: The TICO …

RE Kast - Cancers, 2022 - mdpi.com
Simple Summary Several elements that are composed of, or related to, neutrophils, have
been shown to inhibit strong immune responses to cancer and promote cancers' growth …

SKAP1 expression in cancer cells enhances colon tumor growth and impairs cytotoxic immunity by promoting Neutrophil Extracellular trap formation via the NFATc1 …

J Gao, J Liu, J Lu, X Zhang, W Zhang, Q Li… - Advanced …, 2024 - Wiley Online Library
The mechanisms underlying the development and progression of colon cancer are not fully
understood. Herein, Src kinase associated phosphoprotein 1 (SKAP1), an immune cell …