Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …

De novo lipogenesis (DNL) is a complex and highly regulated process in which
carbohydrates from circulation are converted into fatty acids that are then used for …

Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

The prevalence of obesity has recently increased dramatically and has contributed to the
increasing prevalence of various pathological conditions, including type 2 diabetes mellitus …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

Metabolic health depends on the brain's ability to control food intake and nutrient use versus
storage, processes that require peripheral signals such as the adipocyte-derived hormone …

Interactions between the brain and distinct adipose depots have a key role in maintaining
energy balance, thereby promoting survival in response to metabolic challenges such as …

Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Leptin is a hormone discovered almost 30 years ago with important implications in
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …