Device profile of the percept PC deep brain stimulation system for the treatment of Parkinson's disease and related disorders

J Jimenez-Shahed - Expert Review of Medical Devices, 2021 - Taylor & Francis
Introduction: Several software and hardware advances in the field of deep brain stimulation
(DBS) have been realized in recent years and devices from three manufacturers are …

Debugging adaptive deep brain stimulation for Parkinson's disease

S Little, P Brown - Movement Disorders, 2020 - Wiley Online Library
Deep brain stimulation (DBS) is a successful treatment for patients with Parkinson's disease.
In adaptive DBS, stimulation is titrated according to feedback about clinical state and …

Pathological pallidal beta activity in Parkinson's disease is sustained during sleep and associated with sleep disturbance

Z Yin, R Ma, Q An, Y Xu, Y Gan, G Zhu, Y Jiang… - Nature …, 2023 - nature.com
Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia.
Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive …

[HTML][HTML] Adaptive Deep Brain Stimulation for sleep stage targeting in Parkinson's disease

C Smyth, MF Anjum, S Ravi, T Denison, P Starr, S Little - Brain stimulation, 2023 - Elsevier
Background Sleep dysfunction is disabling in people with Parkinson's disease and is linked
to worse motor and non-motor outcomes. Sleep-specific adaptive Deep Brain Stimulation …

Diurnal modulation of subthalamic beta oscillatory power in Parkinson's disease patients during deep brain stimulation

JJ van Rheede, LK Feldmann, JL Busch… - npj Parkinson's …, 2022 - nature.com
Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson's
disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS) …

Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson's disease

MF Anjum, C Smyth, R Zuzuárregui, DJ Dijk… - Nature …, 2024 - nature.com
Sleep disturbance is a prevalent and disabling comorbidity in Parkinson's disease (PD). We
performed multi-night (n= 57) at-home intracranial recordings from electrocorticography and …

The neurophysiology of sleep in Parkinson's disease

H Zahed, JRP Zuzuarregui, R Gilron… - Movement …, 2021 - Wiley Online Library
Sleep disturbances are among the most common nonmotor complications of Parkinson's
disease (PD), can present in prodromal stages, and progress with advancing disease. In …

[HTML][HTML] Pallidal activities during sleep and sleep decoding in dystonia, Huntington's, and Parkinson's disease

Z Yin, Y Jiang, T Merk, WJ Neumann, R Ma, Q An… - Neurobiology of …, 2023 - Elsevier
Background Sleep disturbances are highly prevalent in movement disorders, potentially due
to the malfunctioning of basal ganglia structures. Pallidal deep brain stimulation (DBS) has …

Deep brain–machine interfaces: sensing and modulating the human deep brain

Y Sui, H Yu, C Zhang, Y Chen, C Jiang… - National Science …, 2022 - academic.oup.com
Different from conventional brain–machine interfaces that focus more on decoding the
cerebral cortex, deep brain–machine interfaces enable interactions between external …

Controlling clinical states governed by different temporal dynamics with closed-loop deep brain stimulation: a principled framework

G Tinkhauser, EM Moraud - Frontiers in neuroscience, 2021 - frontiersin.org
Closed-loop strategies for deep brain stimulation (DBS) are paving the way for improving the
efficacy of existing neuromodulation therapies across neurological disorders. Unlike …