Research on the discovery and characterization of small, regulatory RNAs in bacteria has
exploded in recent years. These sRNAs act by base pairing with target mRNAs with which …

Hfq is a ubiquitous, Sm‐like RNA binding protein found in most bacteria and some archaea.
Hfq binds small regulatory RNAs (sRNAs), facilitates base pairing between sRNAs and their …

Small non-coding RNAs (sRNAs) are critical post-transcriptional regulators of gene
expression. Distinct RNA-binding proteins (RBPs) influence the processing, stability and …

Small ribonucleoproteins (sRNPs) target nascent precursor RNAs to guide folding,
modification, and splicing during transcription. Yet, rapid co-transcriptional folding of the …

Most of the sequenced bacterial genomes contain a gene encoding a protein known as Hfq
that resembles the eukaryotic RNA-binding proteins of the LSm family. It was originally …

Base-pairing interactions between nucleic acids mediate target recognition in many
biological processes. We developed a super-resolution imaging and modeling platform that …

ABSTRACT RNA-binding proteins chaperone the biological functions of noncoding RNA by
reducing RNA misfolding, improving matchmaking between regulatory RNA and targets, and …

The RNA chaperone Hfq is a key player in small RNA (sRNA)-mediated regulation of target
mRNAs in many bacteria. The absence of this protein causes pleiotropic phenotypes such …

In Escherichia coli, the essential motor protein Rho promotes transcription termination in a
tightly controlled manner that is not fully understood. Here, we show that the general post …

Abstract The Sm protein Hfq chaperones small non-coding RNAs (sRNAs) in bacteria,
facilitating sRNA regulation of target mRNAs. Hfq acts in part by remodeling the sRNA and …