Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted …

L Osmani, F Askin, E Gabrielson, QK Li - Seminars in cancer biology, 2018 - Elsevier
Recent large scale genomic studies from the Clinical Lung Cancer Genome Project have
identified different driver gene mutations in the subtypes of non-small cell lung carcinoma …

Biomarker development in the precision medicine era: lung cancer as a case study

AJ Vargas, CC Harris - Nature reviews cancer, 2016 - nature.com
Precision medicine relies on validated biomarkers with which to better classify patients by
their probable disease risk, prognosis and/or response to treatment. Although …

Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer

JJ Smith, NG Deane, F Wu, NB Merchant, B Zhang… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Staging inadequately predicts metastatic risk in patients with colon
cancer. We used a gene expression profile derived from invasive, murine colon cancer cells …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Imaging mass spectrometry

LA McDonnell, RMA Heeren - Mass spectrometry reviews, 2007 - Wiley Online Library
Imaging mass spectrometry combines the chemical specificity and parallel detection of mass
spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain …

Strategies for discovering novel cancer biomarkers through utilization of emerging technologies

V Kulasingam, EP Diamandis - Nature clinical practice Oncology, 2008 - nature.com
The introduction of technologies such as mass spectrometry and protein and DNA arrays,
combined with our understanding of the human genome, has enabled simultaneous …

Mass spectrometry imaging for clinical research–latest developments, applications, and current limitations

PM Vaysse, RMA Heeren, T Porta, B Balluff - Analyst, 2017 - pubs.rsc.org
Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry

JM Wiseman, DR Ifa, Q Song… - Angewandte Chemie …, 2006 - Wiley Online Library
Mass spectrometry (MS) is an increasingly indispensable tool in the biological sciences.
Innovations in methods of creating, analyzing (mass), dissociating, reacting, and collecting …

Molecular imaging by mass spectrometry—looking beyond classical histology

K Schwamborn, RM Caprioli - Nature Reviews Cancer, 2010 - nature.com
Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)
is a new and effective tool for molecular studies of complex biological samples such as …

Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry

S Khatib-Shahidi, M Andersson, JL Herman… - Analytical …, 2006 - ACS Publications
Imaging mass spectrometry (IMS) that utilizes matrix-assisted laser desorption/ionization
(MALDI) technology can provide a molecular ex vivo view of resected organs or whole-body …