G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

Within recent decades glucagon receptor (GcgR) agonism has drawn attention as a
therapeutic tool for the treatment of type 2 diabetes and obesity. In both mice and humans …

G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to
respond to specific cues in their environment. However, the relationship between stimulus …

Aims/hypothesis Diabetes mellitus is associated with impaired insulin secretion, often
aggravated by oversecretion of glucagon. Therapeutic interventions should ideally correct …

Receptor activity-modifying proteins (RAMPs) modulate the activity of many Family B
GPCRs. We show that RAMP2 directly interacts with the glucagon receptor (GCGR), a …

Class BG protein-coupled receptors (GPCRs) respond to paracrine or endocrine peptide
hormones involved in control of bone homeostasis, glucose regulation, satiety, and gastro …

The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs)
is formed through the association of the calcitonin receptor-like receptor (CLR) and one of …

Abstract Objective Glucagon-like peptide-1 (GLP-1) neurons in the hindbrain densely
innervate the dorsomedial hypothalamus (DMH), a nucleus strongly implicated in body …

Receptor activity–modifying proteins (RAMPs) have been shown to modulate the functions
of several G protein–coupled receptors (GPCRs), but potential direct interactions among the …

ABSTRACT G protein-coupled receptors (GPCRs) comprise the largest class of membrane
proteins in the human genome, with a common denominator of seven-transmembrane …