Ibuprofen is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2 arylpropionic acid
(2-APA) class. A common structural feature of 2-APA NSAIDs is a sp 3-hybridised tetrahedral …

BACKGROUND:: Preterm and full-term neonates admitted to the neonatal intensive care unit
or elsewhere in the hospital are routinely subjected to invasive procedures that can cause …

Background Indomethacin is the conventional treatment for patent ductus arteriosus in
preterm infants. However, its use is associated with various side effects. In a prospective …

Recent advances in neurobiology and clinical medicine have established that the fetus and
newborn may experience acute, established, and chronic pain. They respond to such …

Indomethacin (INDO) and, more recently, ibuprofen (IBU) have been used to treat
haemodynamically significant patent ductus arteriosus (PDA) in preterm infants. Both are …

A prospective randomized controlled trial was performed to compare the effects of ibuprofen
with indomethacin on cerebral hemodynamics measured using near infrared spectroscopy …

Background Patent ductus arteriosus is a common complication of prematurity that
frequently requires surgical or medical treatment. The benefit of prophylactic treatment by …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Ibuprofen is a nonsteroidal anti‐
inflammatory agent that induces closure of the patent ductus arteriosus in neonates.• Few …

Patent ductus arteriosus (PDA) is a common clinical condition in preterm infants. Preterm
newborns with PDA are at greater risk for several morbidities, including higher rates of …

NSAIDs are generally considered to be safe and well tolerated, but, even with the advent of
selective COX-2 inhibitors, nephrotoxicity remains a concern. An impaired renal perfusion …