Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently
needed on a global basis because treatment failure is an increasing problem. Drug …

A subject of extensive study in evolutionary theory has been the issue of how neutral,
redundant copies can be maintained in the genome for long periods of time. Concurrently …

Leishmania are eukaryotic parasites that have retained the ability to produce extracellular
vesicles (EVs) through evolution. To date, it has been unclear if different DNA entities could …

Leishmania parasites cause a spectrum of clinical pathology in humans ranging from
disfiguring cutaneous lesions to fatal visceral leishmaniasis. We have generated a reference …

Visceral leishmaniasis is a potentially fatal disease endemic to large parts of Asia and Africa,
primarily caused by the protozoan parasite Leishmania donovani. Here, we report a high …

Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and
potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major …

Leishmania has a plastic genome, and drug pressure can select for gene copy number
variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to …

Abstract The Leishmania tarentolae Parrot-TarII strain genome sequence was resolved to an
average 16-fold mean coverage by next-generation DNA sequencing technologies. This is …

In eukaryotes, the number and rough organization of chromosomes is well preserved within
isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent …

Aneuploidy is known to be deleterious and underlies several common human diseases,
including cancer and genetic disorders such as trisomy 21 in Down's syndrome. In contrast …