The fungal cell wall is located outside the plasma membrane and is the cell compartment
that mediates all the relationships of the cell with the environment. It protects the contents of …

Fungi and mammals share a co-evolutionary history and are involved in a complex web of
interactions. Studies focused on commensal bacteria suggest that pathological changes in …

The body is host to a wide variety of microbial communities from which the immune system
protects us and that are important for the normal development of the immune system and for …

Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to
peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave …

The lung naturally resists Aspergillus fumigatus (Af) in healthy individuals, but multiple
conditions can disrupt this resistance, leading to lethal invasive infections. Core processes …

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger
intracellular signaling cascades that initiate and direct innate and adaptive immune …

Our understanding of immunity to fungal pathogens has advanced considerably in recent
years. Particularly significant have been the parallel discoveries in the C-type lectin receptor …

The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

Dectin-1 is an innate immune pattern recognition receptor (PRR) that, through its ability to
bind β-glucans, is involved in the recognition of several pathogenic fungi. Dectin-1 can …

Respiratory infections and diseases are among the leading causes of death worldwide, and
effective treatments probably require manipulating the inflammatory response to pathogenic …