Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important
component of the extracellular matrix. This leads to the remodelling of the extracellular …

Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer.
The key involvement of angiogenesis in tumor growth and metastasis has started to redefine …

Angiogenesis is a critical process required for tumor progression. Newly formed blood
vessels provide nutrition and oxygen to the tumor contributing to its growth and …

Angiogenesis is required in cancer, including gynecological cancers, for the growth of
primary tumors and secondary metastases. Development of anti-angiogenesis therapy in …

Cancer gene therapy requires a safe and effective gene delivery system. Polymer-and lipid-
coated magnetic nanocrystals have been used to deliver silencing RNA, but synthesizing …

Tumour blood vessels are gateways for distant metastasis. Recent studies have revealed
that tumour endothelial cells (TECs) demonstrate distinct phenotypes from their normal …

An important concept in tumor angiogenesis is that tumor endothelial cells (TECs) are
genetically normal and homogeneous. However, we previously reported that TECs differ …

Members of the bone morphogenetic protein (BMP) family have been implicated in the
development and maintenance of vascular systems. Whereas members of the BMP-2/4 and …

Tumor endothelial cells (TECs) are therapeutic targets in anti-angiogenic therapy. Contrary
to the traditional assumption, TECs can be genetically abnormal and might also acquire …

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) has been identified as a
major receptor for oxidized low-density lipoprotein (ox-LDL) in endothelial cells, monocytes …