Dosimetry modeling and point of departure (POD) estimation using in vitro data are essential
for mechanism-based hazard identification and risk assessment. This study aimed to …

Polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, is known to
cause lung toxicity, including inflammation and pulmonary fibrosis. In this study, we aimed to …

Next-generation risk assessment (NGRA) has emerged as a promising alternative to non-
animal studies owing to the increasing demand for the risk assessment of inhaled toxicants …

Guanidine disinfectants are important chemical agents with a broad spectrum of activity that
are effective against most microorganisms. Chlorhexidine, one of the most used guanidine …

Inhalation exposure to polyhexamethylene guanidine phosphate (PHMG-P), one of the
primary biocides used in humidifier disinfectants, caused a fatal pulmonary disease in …

In this study, we investigated the potential mechanisms by which polyhexamethylene
guanidine phosphate (PHMG-p), a known respiratory irritant, may contribute to lung cancer …

Humidifier disinfectant (HD) is a causative agent of atypical lung injury reported in 2011 in
South Korea, and various diseases caused by HD after exposure cessation have been …

Some drugs or chemicals exhibit different safety profiles in newborns/young children
compared to adults. Polyhexamethyleneguanidine phosphate (PHMG-P) has been …

Under various cellular stress conditions, including exposure to toxic chemicals, RNA-binding
proteins (RBPs), including Ras GTPase-activating protein-binding protein 1 (G3BP1) …

Prostate cancer (PCa), an extremely common malignancy in males, is the most prevalent
disease in several countries. Norcantharidin (NCTD) has antiproliferation, antimetastasis …