The term 'matricellular'has been applied to a group of extracellular proteins that do not
contribute directly to the formation of structural elements in vertebrates but serve to modulate …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Nutrient transporters have been explored for biomimetic delivery targeting the brain. The
albumin-binding proteins (eg, SPARC and gp60) are overexpressed in many tumors for …

Redox homeostasis is vital for cell survival. Nowadays, developing novel nanoagents that
can efficiently break the redox homeostasis, which includes improving the reactive oxygen …

Albumin nanovectors represent one of the most promising carriers recently generated
because of the cost-effectiveness of their fabrication, biocompatibility, safety, and versatility …

Tumor growth is essentially the result of an evolving cross-talk between malignant and
surrounding stromal cells (fibroblasts, endothelial cells and inflammatory cells). This …

The ability to effectively target a tumor to achieve complete regression and cure is the
ultimate goal that drives our need to better understand tumor biology. Recently, SPARC has …

A new approach to drug design based on nanoparticles and related nanostructures for
effective drug delivery, is of great importance in future medical treatment, especially for …

Abstract Secreted Protein Acidic and Rich in Cystein (SPARC)/osteonectin is a nonstructural
matricellular protein involved in cell-matrix interaction during tissue remodeling and …

Although many clinical studies have found a correlation of SPARC expression with
malignant progression and patient survival, the mechanisms for SPARC function in …