Chronic kidney disease (CKD) is a debilitating pathology with various causal factors,
culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation …

Nowadays, there are some molecules that have shown over the years a high capacity to act
against relevant pathologies such as cardiovascular disease, neurodegenerative disorders …

The development of drugs with rapid distribution in the kidney and long-term retention in the
renal tubule is a breakthrough for enhanced treatment of acute kidney injury (AKI). Here, l …

Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

For years, there have been studies based on the use of natural compounds plant-derived as
potential therapeutic agents for various diseases in humans. Curcumin is a phenolic …

Occupational or environmental exposures to heavy metals produce several adverse health
effects. The common mechanism determining their toxicity and carcinogenicity is the …

Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma
longa (turmeric). This medicinal compound has different biological activities, including …

Nuclear factor erythroid 2 p45-related factor (2Nrf2) is an essential leucine zipper protein
(bZIP) that is primarily located in the cytoplasm under physiological conditions. Nrf2 …

Background NLRP3 inflammasome mediates IL-1β maturation, therefore plays a vital role in
the development of IBD. Curcumin is known for possessing strong anti-inflammatory …

Over 10% of the global population suffers from kidney disease. However, only kidney
replacement therapies, which burden medical expenses, are currently effective in treating …