In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

During late fetal life, Schwann cells in the peripheral nerves singled out by the larger axons
will transit through a promyelinating stage before exiting the cell cycle and initiating myelin …

Schwann cell development and peripheral nerve myelination require the serial expression
of transcriptional activators, such as Sox10, Oct6 (also called Scip or Pou3f1) and Krox20 …

The past 15 years have witnessed the identification of more than 25 genes responsible for
inherited neuropathies in humans, many associated with primary alterations of the myelin …

Correct myelination is crucial for the function of the peripheral nervous system. Both positive
and negative regulators within the axon and Schwann cell function to ensure the correct …

The mechanisms that coordinate and balance a complex network of opposing regulators to
control Schwann cell (SC) differentiation remain elusive. Here we demonstrate that zinc …

The different gene members of the Egr family of transcriptional regulators have often been
considered to have related functions in brain, based on their co-expression in many cell …

Myelin is essential for the rapidity of saltatory nerve conduction, and also provides trophic
support for axons to prevent axonal degeneration. Two critical determinants of myelination …

MicroRNAs, by modulating gene expression, have been implicated as regulators of various
cellular and physiological processes, including differentiation, proliferation, and cancer …

The inducible zinc finger transcription factors EGR1, EGR2, and EGR3 regulate the
expression of numerous genes involved in differentiation, growth, and response to …