Oxygen-sensing neurons in the central nervous system

JA Neubauer, J Sunderram - Journal of Applied Physiology, 2004 - journals.physiology.org
This mini-review summarizes the present knowledge regarding central oxygen-
chemosensitive sites with special emphasis on their function in regulating changes in …

Task2 potassium channels set central respiratory CO2 and O2 sensitivity

C Gestreau, D Heitzmann, J Thomas… - Proceedings of the …, 2010 - National Acad Sciences
Task2 K+ channel expression in the central nervous system is surprisingly restricted to a few
brainstem nuclei, including the retrotrapezoid (RTN) region. All Task2-positive RTN neurons …

Acid sensitivity and ultrastructure of the retrotrapezoid nucleus in Phox2b‐EGFP transgenic mice

RM Lazarenko, TA Milner, SD Depuy… - Journal of …, 2009 - Wiley Online Library
The retrotrapezoid nucleus (RTN) contains noncholinergic noncatecholaminergic
glutamatergic neurons that express the transcription factor Phox2b (chemically coded or “cc” …

[HTML][HTML] The c-FOS protein immunohistological detection: a useful tool as a marker of central pathways involved in specific physiological responses in vivo and ex vivo

AS Perrin-Terrin, F Jeton, A Pichon… - Journal of visualized …, 2016 - ncbi.nlm.nih.gov
Many studies seek to identify and map the brain regions involved in specific physiological
regulations. The proto-oncogene c-fos, an immediate early gene, is expressed in neurons in …

Current perspectives for the use of gonane progesteronergic drugs in the treatment of central hypoventilation syndromes

C Loiseau, F Cayetanot, F Joubert… - Current …, 2018 - ingentaconnect.com
Background: Central alveolar hypoventilation syndromes (CHS) encompass
neurorespiratory diseases resulting from congenital or acquired neurological disorders …

Hypoxia‐sensing properties of the newborn rat ventral medullary surface in vitro

N Voituron, A Frugière, J Champagnat… - The Journal of …, 2006 - Wiley Online Library
The ventral medullary surface (VMS) is a region known to exert a respiratory stimulant effect
during hypercapnia. Several studies have suggested its involvement in the central inhibition …

Key brainstem structures activated during hypoxic exposure in one-day-old mice highlight characteristics for modeling breathing network in premature infants

F Joubert, C Loiseau, AS Perrin-Terrin… - Frontiers in …, 2016 - frontiersin.org
We mapped and characterized changes in the activity of brainstem cell groups under
hypoxia in one-day-old newborn mice, an animal model in which the central nervous system …

Diencephalic and mesencephalic influences on ponto-medullary respiratory control in normoxic and hypoxic conditions: an in vitro study on central nervous system …

N Voituron, A Frugiere, F Gros, JM Macron, L Bodineau - Neuroscience, 2005 - Elsevier
We investigated the effects of the diencephalon and mesencephalon on the central
respiratory drive originating from ponto-medullary regions in normoxic and hypoxic …

The kreisler mutation leads to the loss of intrinsically hypoxia-activated spots in the region of the retrotrapezoid nucleus/parafacial respiratory group

N Voituron, A Frugiere, LC Mc Kay… - Neuroscience, 2011 - Elsevier
Acute hypoxia elicits a biphasic respiratory response characterized in the newborn by a
transient hyperventilation followed by a severe decrease in respiratory drive known as …

Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABAA …

N Picard, S Guenin, N Larnicol, Y Perrin - Neuroscience, 2008 - Elsevier
Caffeine is a widely used psychostimulant freely crossing the placental barrier. At the doses
usually absorbed, it acts as an antagonist of both A1 and A2A adenosine receptors …