Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …

The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …

Neuropathic pain is often caused by injury and diseases that affect the somatosensory
system. Although pain development has been well studied, pain recovery mechanisms …

Inflammatory processes and microglia activation accompany most of the pathophysiological
diseases in the central nervous system. It is proven that glial pathology precedes and even …

Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS,
microglia play an important role in the monitoring and intervention of synaptic and neuron …

Microglia are brain-resident immune cells with a repertoire of functions in the brain.
However, the extent of their interactions with the vasculature and potential regulation of …

In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …