Estrogens and estrogen-like molecules can modify the biology of several cell types.
Estrogen receptors alpha (ERα) and beta (ERβ) belong to the so-called classical family of …

Estrogens play a crucial physiological function in the brain; however, debates exist
concerning the role of estrogens in Alzheimer's disease (AD). Women during pre-, peri-, or …

Cancer and neurodegeneration are different classes of diseases that share the involvement
of mitochondria in their pathogenesis. Whereas the high glycolytic rate (the so-called …

Objectives To examine differences in prefrontal-executive function between breast cancer
(BC) survivors with and without a history of chemotherapy treatment compared with healthy …

Estrogens are the primary female sex hormones and play important roles in both
reproductive and non-reproductive systems. Estrogens can be synthesized in non …

Nonhuman primates are useful for the study of age-associated changes in the brain and
behavior in a model that is biologically proximal to humans. The Aβ and tau proteins, two …

Alzheimer's disease (AD) is a neurodegenerative disease responsible for almost half of all
dementia cases in the world and progressively increasing. The etiopathology includes …

Neurosteroids are synthesized de novo in the nervous system; they mainly moderate
neuronal excitability, and reach target cells via the extracellular pathway. The synthesis of …

Steroid hormones (eg estrogens, androgens, progestagens) which are synthesized de novo
or metabolized within the CNS are called neurosteroids. There is substantial evidence from …

Abnormal tau accumulation can lead to the development of neurodegenerative diseases.
P301S mice overexpress the human tau mutated gene, resulting in tau …