Availability of artificial light and light-emitting devices have altered human temporal life,
allowing 24-hour healthcare, commerce and production, and expanding social life around …

Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

Whether amino acids act on cellular insulin signaling remains unclear, given that increased
circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here …

Cyclical expression of cell-autonomous circadian clock components and key metabolic
regulators coordinate often discordant and distant cellular processes for efficient …

The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …

The circadian clock system consists of a central clock located in the suprachiasmatic
nucleus in the hypothalamus and peripheral clocks in peripheral tissues. Peripheral clocks …

Time-restricted eating (TRE) is a dietary intervention that limits food consumption to a
specific time window each day. The effect of TRE on body weight and physiological …

Circadian clock proteins are endogenous timing mechanisms that control the transcription of
hundreds of genes. Their integral role in coordinating metabolism has led to their scrutiny in …

Background Diabetes is the seventh leading cause of death in the USA, and disruption of
circadian rhythms is gaining recognition as a contributing factor to disease prevalence. This …

Background Phenolic compounds are one of the most heterogeneous group of plant
secondary metabolites with over 50,000 diverse molecules identified so far. Despite the low …